联系方式：

常州大学威廉希尔体育

江苏省常州市武进区科教城常州大学测试楼A座802

Email: zhaoshuai@cczu.edu.cn

科研之友（Scholar Mate）主页：https://www.scholarmate.com/P/emIFV3

研究方向：

I. 天然产物以及重要生物活性分子结构导向的有机合成方法学研究

  1）惰性C-H键活化

  2）可见光催化

II. G蛋白偶联受体相关的药物化学研究

教育及工作经历：

2018.12至2019.12  美国Scripps 研究所（The Scripps Research Institute）访问学者，导师：余金权教授，研究方向：碳氢活化及DNA编码化合物库

2015.6月至今   常州大学威廉希尔体育药学系

2010.9至2015.6  兰州大学化学化工学院有机化学专业博士导师：许鹏飞教授，研究方向：不对称有机催化

2006.9至2010.6  兰州大学化学化工学院化学基地专业学士

基金课题：

兰州大学中央高校基本科研业务费专项资金优秀研究生项目，lzujbky-2014-242，有机催化合成吲哚螺环结构的研究，2014/1-2015/6，1万元，已结题，主持

国家自然科学基金面上项目，21172097，基于不对称有机催化的天然产物全合成研究，2012/1-2015/12，60万元，已结题，参加

常州大学科研启动经费，2015/10-2017/10，已结题，主持

国家自然科学基金青年科学基金项目，21602018，手性季铵盐氟化物催化非活化羧酸酯的α位不对称烷基化反应研究，2017/1-2019/1, 20万元，已结题，主持

代表性研究成果：

1. Shuai Zhao, Shengchao Guo, Chan Yang, Zheng Gong, Yaomin Wang, Yingli Jia, Xinyu Jiang, Liwei Xu, Li Shi, Xiao Yu, Jinpeng Sun, Yan Zhang, Xin Chen*.Cell active and functionally-relevant small-molecule agonists of calcitoninreceptor. Bioorg. Chem.2020, 96, 103596.

2. Zhoulong Fan,^‡Shuai Zhao,^‡ Tao Liu, Peng-Xiang Shen, Zi-Ning Cui, Zhe Zhuang, Qian Shao, Jason S. Chen, Anokha S. Ratnayake, Mark E. Flanagan, Dominik K. Kölmel, David W. Piotrowski, Paul Richardsond, Jin-Quan Yu*. Merging C(sp3)–H activation with DNA-encoding. Chem. Sci.2020,11, 12282.

3. Shuai Zhao, Zhi-Li Chen, Xue Rui, Ming-Mei Gao, Xin Chen*. Asymmetric Allylic Amination of Morita–Baylis–Hillman Adducts with Simple Aromatic Amines by Nucleophilic Amine Catalysis. Synlett. 2019, 30, 703.

4. Shuai Zhao, Lei Jin, Zhi-Li Chen, Xue Rui, Jia-Yi He, Ran Xia, Ke Chen, Xiang-Xiang Chen, Zi-Jian Yin, Xin Chen*. Asymmetric synthesis of multifunctional aryl allyl ethers by nucleophilic catalysis. RSC Adv.2019,9, 11585.

5. Lei Jin, Shuai Zhao, Xin Chen*. Synthesis of Both Enantiomers of Chiral Phenylalanine Derivatives Catalyzed by Cinchona Alkaloid Quaternary Ammonium Salts as Asymmetric Phase Transfer Catalysts. Molecules.2018,23, 1421.

6. Qinting Wang, Shuai Zhao, Lei Jin, Xin Chen*.Synthesis of Fmoc-protected (S)-3,5-Dibromophenylalanine in the Presence of a Phase Transfer Catalyst or a Chiral Catalyst. Chin. J. Org. Chem. 2016,36, 2242.

7. Yuan-Yuan Zhao, Shuai Zhao, Ji-Kang Xie, Xiu-Qin Hu, Peng-Fei Xu*. Synthesis of Spirocyclic Oxindole Dihydrothiophenes by DBU Catalyzed [3+2] Annulation of Morita−Baylis−Hillman Carbonates with Isothiocyanates. J. Org. Chem. 2016,81, 10532.

8. Ting Xie, Yu Xiao, Shuai Zhao, Xiu-Qin Hu, Peng-Fei Xu*. Catalyst-Free Chemoselective Synthesis of 3,4-Dihydroquinazoline-2-thiones and 2‑Imino[1,3] benzothiazines. J. Org. Chem. 2016, 81, 10499.

9. Shuai Zhao, Yuan-Yuan Zhao, Jun-Bing Lin, Yong-Ming Liang, Peng-Fei Xu*. Organocatalyzed Asymmetric Vinylogous Allylic-Allylic Alkylation of Morita-Baylis-Hillman Carbonates with Olefinic Azlactones: Facile Access to Chiral Multifunctional α-Amino Acid Derivatives. Org. Lett. 2015, 17, 3206.

10. Shuai Zhao, Jun-Bing Lin, Yuan-YuanZhao, Yong-Ming Liang, Peng-Fei Xu*. Hydrogen-bond-directed formal [5+1] annulations of oxindoles with ester-linked bisenones: facile access to chiral spirooxindole δ-Lactones. Org. Lett.2014, 16, 1802.