钱明成简介
联系方式: 常州大学威廉希尔体育 江苏省常州市武进区科教城常州大学测试楼A座802
Email: mqian2019@cczu.edu.cn
研究方向: 1、G-蛋白偶联受体(GPCR) 变构调节剂的设计、合成及生物活性研究; 2、GPCR二聚化的化学生物学研究; 3、多靶点GPCR配体小分子的设计、合成及生物活性研究; 4、GPCR荧光探针的设计、合成及作用机制研究。
主要教育和工作经历:
2019.04 -至今常州大学学院教师,硕士生导师 2018.01 - 2018.12 根特大学威廉希尔体育,助理研究员 2013 - 2018比利时根特大学 (Ghent University),威廉希尔体育,药学博士 江苏省双创博士,常州市龙城英才
代表性科研成果: 1. M. Qian, X. Jiang, M. Zhang, L. Hu, H. Liu, S. Zhao, X. Zhou*, X. Chen*. Synthesis, biological evaluation, and docking study of ring-opening amide analogues of matrine as anti-tumor agents. Chem. Biodiversity. 2021. DOI: 10.1002/cbdv.202000979. 2. M. Qian, A. Ricarte, E. Wouters, J.A.R. Dalton, M.D.P. Risseeuw, J. Giraldo, S. Van Calenbergh*. Discovery of a true bivalent dopamine D2 receptor agonist. Eur. J. Med. Chem. 2021, 212, 113151. 3. V. Fernández-Dueñas*,#, M. Qian#, J. Argerich, C. Amaral, M.D.P. Risseeuw, S. Van Calenbergh*, F. Ciruela*. Design, synthesis and characterization of a new series of fluorescent metabotropic glutamate receptor type 5 negative allosteric modulators.Molecules 2020, 25, 1532. #Co-first author 4. Z. Zhao, G. Liu, Y. Meng, J. Tian, X. Chen, M. Shen, Y. Li, B. Li, Cong Gao, S. Wu, C. Li*, X. He, R. Jiang, M. Qian*, X. Zheng*. Synthesis and anti-tyrosinase mechanism of the substituted vanillyl cinnamate analogues. Bioorg. Chem. 2019. 93, 103316. * Corresponding author 5. M. Qian, E. Wouters, J. A. R. Dalton, M. D. P. Risseeuw, R. A. J. Crans, C. Stove, J. Giraldo, K. Van Craenenbroeck, S. Van Calenbergh*. Synthesis toward bivalent ligands for the dopamine D2 and metabotropic glutamate 5 receptors. J. Med. Chem. 2018, 61, 8212−8225. 6. M. Qian, L. Vasudevan, J. Huysentruyt, M. D. P. Risseeuw, C. Stove, P. M. L. Vanderheyden, K. Van Craenenbroeck, S. Van Calenbergh*. Design, synthesis and biological evaluation of novel bivalent ligands targeting dopamine D2-like receptors and the µ opioid receptor. ChemMedChem 2018, 13, 944 – 956.
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